Central sensitization in rheumatoid arthritis and psoriatic arthritis is associated with symptom burden than inflammatory activity: a cross-sectional study.

A cross-sectional study found that central sensitization in patients with rheumatoid arthritis and psoriatic arthritis correlates more strongly with overall symptom burden—including pain, fatigue, and psychological distress—than with objective markers of inflammatory disease activity. These findings suggest that central sensitization may persist independently of inflammation, which has important implications for physical therapists managing patients with chronic inflammatory arthritis who continue to report high pain levels despite controlled disease. Addressing central sensitization through pain neuroscience education and targeted rehabilitation strategies may be warranted in this population.

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